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Monday, January 22, 2018

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Kleberg Foundation grants $3.2 million
Around Texas

April, 2009

The Kleberg Foundation provided a $3.2 million grant to fund the research of Joel B. Baseman, Ph.D., professor and chair of microbiology and immunology. The grant, awarded in 2007, is allowing Dr. Baseman to advance the development of new strategies to diagnose and reduce airway disease in infants, children and adults. His discovery of the Community-Acquired Respiratory Distress Syndrome Toxin (CARDS TX) is the most important finding in this field since the discovery decades ago of the toxins of diphtheria and pertussis.

According to the American Lung Association, lung disease is the third-leading killer in America, responsible for 1 in 6 deaths. Lung disease and other breathing problems constitute one of the leading causes of death in children younger than 1 year old. Today, more than 35 million Americans are living with chronic lung disease such as asthma, and chronic obstructive pulmonary disease (COPD) otherwise known as emphysema and chronic bronchitis.

Dr. Baseman said the grant has allowed his research team to make considerable progress toward developing new therapies for these debilitating diseases.

"Our findings indicate that the environment of the lung triggers toxin production. Because of the Kleberg Foundation grant, we have been able to develop state-of-the-art systems to observe infection and toxin production using live cell and whole animal imaging," Dr. Baseman said. Funding recently provided for three postdoctoral fellows to be hired to work on live cell and animal imaging of CARDS TX. The researchers are also examining the connection between encephalitis in children and CARDS TX. They plan to test potential vaccines within the next two years.

"We believe CARDS TX is a most important virulence factor of airway diseases, and these key studies, propelled by the Kleberg Foundation, will lead to innovative treatments of serious acute and chronic pulmonary pathologies," Dr. Baseman said.

Dr. Baseman has already published his findings in the journals Infection and Immunity and Proceedings of the National Academy of Sciences and has presented them at the American Thoracic Society in San Francisco, the Academy of Allergy, Asthma and Immunology in Philadelphia and the National Institute of Allergy and Infectious Diseases in Virginia.


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